Pair Name | Tanshinone I, Paclitaxel | ||
Phytochemical Name | Tanshinone I (PubChem CID: 114917 ) | ||
Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
Structure of Phytochemical |
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MOL
3D
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Tanshinone I, Paclitaxel | |||
Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
Down-regulation | Expression | BCL2 | hsa596 | |
Up-regulation | Expression | CDKN1A | hsa1026 | |
Up-regulation | Expression | CDKN2A | hsa1029 | |
In Vitro Model | A2780 | Ovarian endometrioid adenocarcinoma | Homo sapiens (Human) | CVCL_0134 |
ID8 | Epithelial Ovarian Cancer | Mus musculus (Mouse) | CVCL_IU14 | |
In Vivo Model | The A2780 cells were injected bilaterally and subcutaneously into the flanks of the nude mice (100 µL, 2×10⁷ cells). | |||
Result | Natural compound Tan-I enhances the efficacy of ovarian cancer to Paclitaxel chemotherapy. The results will help to supply the potential clinical use of ovarian carcinoma cells. |
No. | Title | Href |
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1 | Natural compound Tan-I enhances the efficacy of Paclitaxel chemotherapy in ovarian cancer. Ann Transl Med. 2020 Jun;8(12):752. doi: 10.21037/atm-20-4072. | Click |