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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Tanshinone I, Paclitaxel
Phytochemical Name Tanshinone I (PubChem CID: 114917 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 230
Pair Name Tanshinone I, Paclitaxel
Disease Info [ICD-11: 2C73] Ovarian cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression CDKN2A hsa1029
In Vitro Model A2780 Ovarian endometrioid adenocarcinoma Homo sapiens (Human) CVCL_0134
ID8 Epithelial Ovarian Cancer Mus musculus (Mouse) CVCL_IU14
In Vivo Model The A2780 cells were injected bilaterally and subcutaneously into the flanks of the nude mice (100 µL, 2×10⁷ cells).
Result Natural compound Tan-I enhances the efficacy of ovarian cancer to Paclitaxel chemotherapy. The results will help to supply the potential clinical use of ovarian carcinoma cells.
03. Reference
No. Title Href
1 Natural compound Tan-I enhances the efficacy of Paclitaxel chemotherapy in ovarian cancer. Ann Transl Med. 2020 Jun;8(12):752. doi: 10.21037/atm-20-4072. Click
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